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    Exposure was increased eszopiclone 2-fold in severely impaired patients compared with the healthy volunteers .
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    No dose adjustment is necessary eszopiclone for patients with mild-to-moderate hepatic impairment .
    LUNESTA should be used with caution in patients eszopiclone with hepatic impairment .
    ) Renal Impairment The pharmacokinetics of eszopiclone were studied in 24 patients with eszopiclone mild, moderate, or severe renal impairment . (See DOSAGE eszopiclone AND ADMINISTRATION .
    AUC and eszopiclone Cmax were similar in the patients compared with demographically matched healthy control subjects .
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    Drug Interactions Eszopiclone is metabolized by CYP3A4 and lunesta black box warning lunesta coupon 2017 lunesta fda approval lunesta night sweats lunesta pill CYP2E1 via demethylation and oxidation .
    There were lunesta and zzzquil lunesta for elderly lunesta side effects weight gain generic for lunesta 3 mg no pharmacokinetic or pharmacodynamic interactions between eszopiclone and paroxetine, digoxin, or warfarin .
    When eszopiclone was coadministered with olanzapine, no pharmacokinetic interaction was detected in levels of eszopiclone or olanzapine, but a pharmacodynamic interaction was seen on eszopiclone a measure of psychomotor function .
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