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Tapentadol was evaluated tapentadol for teratogenic effects in rats and rabbits following intravenous and subcutaneous administration during organogenesis .
Embryofetal toxicity such as delays in skeletal maturation and cerebral ventricular dilation was observed in rats concomitant with maternal toxicity at subcutaneous doses tapentadol of 10 mg/kg/day or greater (plasma AUC exposure less than maximum anticipated clinical exposure) .
Subcutaneous administration of tapentadol to rabbits revealed embryofetal toxicity at doses of 10-24 mg/kg/day (AUC exposure 1 to 2 fold the maximum anticipated human exposure), along with tapentadol 150 mg nucynta coupon nucynta and tramadol nucynta vs opana nucynta off the market reduced fetal viability, skeletal delays and other variations, and multiple malformations including gastroschisis/thoracogastroschisis, amelia/phocomelia and cleft palate at 10-24 mg/kg/day, and ablepharia, encephalopathy and spina bifida at 24 mg/kg/day .
There were no teratogenic effects observed in similar studies conducted in rats and rabbits via the intravenous tapentadol route (up to 15 mg/kg/day) .
nucynta an opioid tapentadol leki nucynta janssen depomed nucynta tapentadol tapentadol tablet uses Embryofetal toxicity, including malformations, may be secondary to maternal toxicity in these species .
Use in lactation There is limited information on the excretion of nucynta strengths palexia cheapoair nucynta vs hydrocodone high nucynta ir reviews tapentadol bcs tapentadol in breast milk .
Tapentadol is excreted tapentadol into milk in lactating rats following oral dosing .
Oral tapentadol administration to rats during lactation resulted in increased postnatal pup mortality, at doses lower than those associated with palexia sr tapentadol online cheap nucynta janssen depomed nucynta like percocet palexia ir what is maternal toxicity (exposure (AUC) less than maximum anticipated clinical exposure) .
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